The dominant-STN phenomenon in bilateral STN DBS for Parkinson's disease.
Identifieur interne : 001580 ( Main/Exploration ); précédent : 001579; suivant : 001581The dominant-STN phenomenon in bilateral STN DBS for Parkinson's disease.
Auteurs : Anna Castrioto [Canada] ; Christopher Meaney ; Clement Hamani ; Filomena Mazzella ; Yu-Yan Poon ; Andres M. Lozano ; Mojgan Hodaie ; Elena MoroSource :
- Neurobiology of disease [ 1095-953X ] ; 2011.
English descriptors
- KwdEn :
- Aged, Deep Brain Stimulation (methods), Double-Blind Method, Female, Functional Laterality (physiology), Humans, Male, Middle Aged, Neural Pathways (physiology), Outcome Assessment (Health Care) (methods), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Recovery of Function (physiology), Subthalamic Nucleus (physiology), Treatment Outcome.
- MESH :
- methods : Deep Brain Stimulation, Outcome Assessment (Health Care).
- pathology : Parkinson Disease.
- physiology : Functional Laterality, Neural Pathways, Recovery of Function, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
In some patients with Parkinson's disease (PD) and bilateral STN-DBS the motor benefit from one STN alone appears similar to the improvement obtained with bilateral STN-DBS. Thus, we hypothesized that some patients have a "dominant-STN," whose stimulation achieves similar results than bilateral stimulation. Twenty-two consecutive PD patients with bilateral STN-DBS were assessed in 4 randomized conditions: bilateral off-stimulation, bilateral on-stimulation, unilateral right- and unilateral left-stimulation. A hierarchical agglomerative cluster analysis of the motor UPDRS scores in these 4 conditions showed that 11 patients (50%) presented with a "dominant-STN." Interestingly, in 3 of these patients the dominant-STN was ipsilateral to the most affected side of the body. Our results support the presence of different phenotypes of response to bilateral STN stimulation. In our sample 50% of the patients presented with a dominant-STN, suggesting that a non-negligible part of PD patients might not need bilateral STN-DBS surgery.
DOI: 10.1016/j.nbd.2010.08.029
PubMed: 20826212
Affiliations:
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Lozano</name></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:20826212</idno><idno type="pmid">20826212</idno><idno type="doi">10.1016/j.nbd.2010.08.029</idno><idno type="wicri:Area/PubMed/Corpus">000C73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C73</idno><idno type="wicri:Area/PubMed/Curation">000C73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C73</idno><idno type="wicri:Area/PubMed/Checkpoint">000C73</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C73</idno><idno type="wicri:Area/Ncbi/Merge">000D37</idno><idno type="wicri:Area/Ncbi/Curation">000D37</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D37</idno><idno type="wicri:Area/Main/Merge">001644</idno><idno type="wicri:Area/Main/Curation">001580</idno><idno type="wicri:Area/Main/Exploration">001580</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The dominant-STN phenomenon in bilateral STN DBS for Parkinson's disease.</title><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name><affiliation wicri:level="4"><nlm:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Meaney, Christopher" sort="Meaney, Christopher" uniqKey="Meaney C" first="Christopher" last="Meaney">Christopher Meaney</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Double-Blind Method</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Pathways (physiology)</term><term>Outcome Assessment (Health Care) (methods)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Recovery of Function (physiology)</term><term>Subthalamic Nucleus (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Outcome Assessment (Health Care)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Neural Pathways</term><term>Recovery of Function</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In some patients with Parkinson's disease (PD) and bilateral STN-DBS the motor benefit from one STN alone appears similar to the improvement obtained with bilateral STN-DBS. Thus, we hypothesized that some patients have a "dominant-STN," whose stimulation achieves similar results than bilateral stimulation. Twenty-two consecutive PD patients with bilateral STN-DBS were assessed in 4 randomized conditions: bilateral off-stimulation, bilateral on-stimulation, unilateral right- and unilateral left-stimulation. A hierarchical agglomerative cluster analysis of the motor UPDRS scores in these 4 conditions showed that 11 patients (50%) presented with a "dominant-STN." Interestingly, in 3 of these patients the dominant-STN was ipsilateral to the most affected side of the body. Our results support the presence of different phenotypes of response to bilateral STN stimulation. In our sample 50% of the patients presented with a dominant-STN, suggesting that a non-negligible part of PD patients might not need bilateral STN-DBS surgery.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Meaney, Christopher" sort="Meaney, Christopher" uniqKey="Meaney C" first="Christopher" last="Meaney">Christopher Meaney</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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